Protein name:
Neurogenic locus notch homolog protein 1 (Notch 1) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization.
Function:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.
Subcellular Location:
Notch 1 intracellular domain
Nucleus
Following proteolytical processing NICD is translocated to the nucleus.
Protein Attributes:
50:
MPRLLAPLLC | LTLLPALAAR | GLRCSQPSGT | CLNGGRCEVA | NGTEACVCSG |
100:
AFVGQRCQDP | SPCLSTPCKN | AGTCYVVDHG | GIVDYACSCP | LGFSGPLCLT |
150:
PLANACLANP | CRNGGTCDLL | TLTEYKCRCP | PGWSGKSCQQ | ADPCASNPCA |
200:
NGGQCLPFES | SYICGCPPGF | HGPTCRQDVN | ECSQNPGLCR | HGGTCHNEIG |
250:
SYRCACRATH | TGPHCELPYV | PCSPSPCQNG | GTCRPTGDTT | HECACLPGFA |
300:
GQNCEENVDD | CPGNNCKNGG | ACVDGVNTYN | CRCPPEWTGQ | YCTEDVDECQ |
350:
LMPNACQNAG | TCHNSHGGYN | CVCVNGWTGE | DCSDNIDDCA | SAACFQGATC |
400:
HDRVASFYCE | CPHGRTGLLC | HLNDACISNP | CNEGSNCDTN | PVNGKAICTC |
450:
PRGYTGPACS | QDVDECALGA | NPCEHAGKCL | NTLGSFECQC | LQGYTGPRCE |
500:
IDVNECISNP | CQNDATCLDQ | IGEFQCICMP | GYEGVYCEIN | TDECASSPCL |
550:
HNGRCVDKIN | EFLCQCPKGF | SGHLCQYDVD | ECASTPCKNG | AKCLDGPNTY |
600:
TCVCTEGYTG | THCEVDIDEC | DPDPCHIGLC | KDGVATFTCL | CQPGYTGHHC |
650:
ETNINECHSQ | PCRHGGTCQD | RDNYYLCLCL | KGTTGPNCEI | NLDDCASNPC |
700:
DSGTCLDKID | GYECACEPGY | TGSMCNVNID | ECAGSPCHNG | GTCEDGIAGF |
750:
TCRCPEGYHD | PTCLSEVNEC | NSNPCIHGAC | RDGLNGYKCD | CAPGWSGTNC |
800:
DINNNECESN | PCVNGGTCKD | MTSGYVCTCR | EGFSGPNCQT | NINECASNPC |
850:
LNQGTCIDDV | AGYKCNCPLP | YTGATCEVVL | APCATSPCKN | SGVCKESEDY |
900:
ESFSCVCPTG | WQGQTCEIDI | NECVKSPCRH | GASCQNTNGS | YRCLCQAGYT |
950:
GRNCESDIDD | CRPNPCHNGG | SCTDGVNAAF | CDCLPGFQGA | FCEEDINECA |
1000:
TNPCQNGANC | TDCVDSYTCT | CPTGFNGIHC | ENNTPDCTES | SCFNGGTCVD |
1050:
GINSFTCLCP | PGFTGSYCQY | DVNECDSRPC | LHGGTCQDSY | GTYKCTCPQG |
1100:
YTGLNCQNLV | RWCDSAPCKN | GGKCWQTNTQ | YHCECRSGWT | GFNCDVLSVS |
1150:
CEVAAQKRGI | DVTLLCQHGG | LCVDEEDKHY | CHCQAGYTGS | YCEDEVDECS |
1200:
PNPCQNGATC | TDYLGGFSCK | CVAGYHGSNC | SEEINECLSQ | PCQNGGTCID |
1250:
LTNTYKCSCP | RGTQGVHCEI | NVDDCHPPLD | PASRSPKCFN | NGTCVDQVGG |
1300:
YTCTCPPGFV | GERCEGDVNE | CLSNPCDPRG | TQNCVQRVND | FHCECRAGHT |
1350:
GRRCESVING | CRGKPCRNGG | VCAVASNTAR | GFICRCPARF | EGATCENDAR |
1400:
TCGSLRCLNG | GTCISGPRSP | TCLCLGSFTG | PECQFPASSP | CVGSNPCYNQ |
1450:
GTCEPTSESP | FYRCLCPAKF | NGLLCHILDY | SFTGAAGRDI | PPPQIEEACE |
1500:
LPECQEDAGN | KVCNLQCNNH | ACGWDGGDCS | LNFNDPWKNC | TQSLQCWKYF |
1550:
SDGHCDSQCN | SAGCLFDGFD | CQLTEGQCNP | LYDQYCKDHF | SDGHCDQGCN |
1600:
SAECEWDGLD | CAEHVPERLA | AGTLVLVVLL | PPDQLRNNSF | HFLRDVSHVL |
1650:
HTNVVFKRDA | QGQQMIFPYY | GREEELRKHP | IKRSAVGWAT | TSLLPGTNGG |
1700:
RQRRELDPMD | IHGSIVYLEI | DNRQCVQSSS | QCFQSATDVA | AFLGALASLG |
1750:
SLNIPYKIEA | VKSETVEPPL | PSQLHLMYVA | AAAFVLLFFV | GCGVLLSRKR |
1800:
RRQHGQLWFP | EGFKVSEASK | KKRREPLGED | SVGLKPLKNA | SDGALMDDNQ |
1850:
NEWGDEDLET | KKFRFEEPVV | LPDLDDQTDH | RQWTQQHLDA | ADLRVSAMAP |
1900:
TPPQGEVDAD | CMDVNVRGPD | GFTPLMIASC | SGGGLETGNS | EEEEDAPAVI |
1950:
SDFIYQGASL | HNQTDRTGET | ALHLAARYSR | SDAAKRLLEA | SADANIQDNM |
2000:
GRTPLHAAVS | ADAQGVFQIL | LRNRATDLDA | RMHDGTTPLI | LAARLAVEGM |
2050:
LEDLINSHAD | VNAVDDLGKS | ALHWAAAVNN | VDAAVVLLKN | GANKDMQNNK |
2100:
EETPLFLAAR | EGSYETAKVL | LDHFANRDIT | DHMDRLPRDI | AQERMHHDIV |
2150:
RLLDEYNLVR | SPQLHGTALG | GTPTLSPTLC | SPNGYLGNLK | SATQGKKARK |
2200:
PSTKGLACSS | KEAKDLKARR | KKSQDGKGCL | LDSSSMLSPV | DSLESPHGYL |
2250:
SDVASPPLLP | SPFQQSPSMP | LSHLPGMPDT | HLGISHLNVA | AKPEMAALAG |
2300:
GSRLAFEPPP | PRLSHLPVAS | SASTVLSTNG | TGAMNFTVGA | PASLNGQCEW |
2350:
LPRLQNGMVP | SQYNPLRPGV | TPGTLSTQAA | GLQHGMMGPI | HSSLSTNTLS |
2400:
PIIYQGLPNT | RLATQPHLVQ | TQQVQPQNLQ | IQPQNLQPPS | QPHLSVSSAA |
2450:
NGHLGRSFLS | GEPSQADVQP | LGPSSLPVHT | ILPQESQALP | TSLPSSMVPP |
2500:
MTTTQFLTPP | SQHSYSSSPV | DNTPSHQLQV | PEHPFLTPSP | ESPDQWSSSS |
2531:
RHSNISDWSE | GISSPPTSMP | SQITHIPEAF | K
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Rat Notch 1
ELISA Kit for Rat Notch 1
ELISA Kit for Rat Notch 1
Polyclonal Antibody for Rat Notch 1
Polyclonal Antibody for Rat Notch 1
Polyclonal Antibody for Rat Notch 1
Monoclonal Antibody for Rat Notch 1
Monoclonal Antibody for Rat Notch 1
Monoclonal Antibody for Rat Notch 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Schwann cell .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION TO 1652-1653
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY